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These multi-target effects could potentially enhance therapeutic profiles compared to GLP-1 receptor agonists like semaglutide, and may differentially influence specific outcomes, such as alcohol intake and weight loss

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This two-step sequential binding mechanism is ECD docking, followed by TMD penetration is unique to peptide agonists and is only resolvable in an intact cell SPRM experiment

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This approach ensured that the impact of GLP-1RAs on outcomes remained consistent across different time intervals